Being able to image inflammation can help doctors diagnose, treat, and predict the outcomes of many diseases. However, there isn’t yet a highly accurate and specific imaging method to detect inflammation. To solve this problem, researchers developed a new technique called CD45-PET imaging. This method provides clear and sensitive pictures of inflammation in different disease models.
One of the key findings is that CD45-PET imaging shows how severe a disease is by producing stronger signals in models of lung and bowel diseases. It works better than the current most-used method, called 18F-fluorodeoxyglucose PET, for detecting inflammation. CD45-PET can also track how inflammation changes over time in specific tissues.
The researchers also created a version of CD45-PET for humans, which successfully detects human immune cells in special mouse models that mimic the human immune system. This new imaging method has great potential to help doctors make better decisions by providing a precise, full-body view of inflammation in patients.
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| From the text: Fig. 1: 89Zr-CD45 nanobody PET probe clearly visualizes immune-cell-rich organs in vivo. |
Salehi Farid, A., Rowley, J.E., Allen, H.H. et al. CD45-PET is a robust, non-invasive tool for imaging inflammation. Nature (2025). https://doi.org/10.1038/s41586-024-08441-6
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